Synthesis, stability, and biological evaluation of 1,3-dihydrobenzo[c]furan analogue of d4T and its SATE pronucleotide

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):943-5. doi: 10.1081/NCN-120022691.

Abstract

The anti-HIV activity and stability studies of 1,3-dihydrobenzo[c]furan analogue of d4T are reported. The corresponding mononucleoside phosphotriester derivative bearing a S-pivaloyl-2-thioethyl (tBuSATE) group, as biolabile phosphate protection, is also studied.

MeSH terms

  • Anti-HIV Agents / chemical synthesis*
  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / pharmacology
  • Benzofurans
  • Cell Line
  • Drug Stability
  • HIV-1 / drug effects
  • HIV-1 / physiology*
  • Half-Life
  • Humans
  • Prodrugs / chemical synthesis*
  • Prodrugs / chemistry
  • Prodrugs / pharmacology
  • Stavudine / analogs & derivatives*
  • Stavudine / chemical synthesis
  • Stavudine / chemistry*
  • Stavudine / pharmacology
  • Stereoisomerism
  • Virus Replication / drug effects

Substances

  • Anti-HIV Agents
  • Benzofurans
  • Prodrugs
  • Stavudine