Abstract
The 8-acetoxy-2-methoxy-10-hydroxy-3,11(13)-guaiaden-12,6-olide 1 and 8,10-diacetoxy-2-methoxy-3,11(13)-guaiadiene-12,6-olide 2 were isolated from Chrysanthemum boreale Makino. Compound 1 inhibited the etoposide-induced apoptosis in U 937 cells with an IC50 value 8.6 microg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antineoplastic Agents, Phytogenic / therapeutic use
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Apoptosis / drug effects*
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Cell Line, Tumor / drug effects
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Chrysanthemum*
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Etoposide
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Humans
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Inhibitory Concentration 50
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Plant Leaves
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Plant Stems
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Sesquiterpenes, Guaiane / administration & dosage
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Sesquiterpenes, Guaiane / chemistry
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Sesquiterpenes, Guaiane / pharmacology*
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Sesquiterpenes, Guaiane / therapeutic use
Substances
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Antineoplastic Agents, Phytogenic
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Plant Extracts
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Sesquiterpenes, Guaiane
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Etoposide