Hazard regression for interval-censored data with penalized spline

Biometrics. 2003 Sep;59(3):570-9. doi: 10.1111/1541-0420.00067.

Abstract

This article introduces a new approach for estimating the hazard function for possibly interval- and right-censored survival data. We weakly parameterize the log-hazard function with a piecewise-linear spline and provide a smoothed estimate of the hazard function by maximizing the penalized likelihood through a mixed model-based approach. We also provide a method to estimate the amount of smoothing from the data. We illustrate our approach with two well-known interval-censored data sets. Extensive numerical studies are conducted to evaluate the efficacy of the new procedure.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biometry
  • Breast Neoplasms / pathology
  • Breast Neoplasms / therapy
  • Data Interpretation, Statistical
  • Female
  • HIV Infections / complications
  • HIV Infections / transmission
  • Hemophilia A / complications
  • Humans
  • Likelihood Functions
  • Linear Models
  • Proportional Hazards Models*
  • Survival Analysis