Abstract
Hepatitis C is one of the leading indications for liver transplantation. Recipients can expect at least a short-term survival equivalent to other indications for liver transplantation. However, the rates of cirrhosis and decompensation development is substantially faster than those rates seen in non-transplant setting. Advances in antiviral therapy are now associated with a sustained virological response of 20% with combination antiviral with interferon and ribavirin. Higher response rates are expected with utilizing pegylated interferon.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Antiviral Agents / therapeutic use
-
Combined Modality Therapy
-
Disease Progression
-
Hepacivirus / genetics
-
Hepacivirus / isolation & purification
-
Hepatitis C, Chronic / complications
-
Hepatitis C, Chronic / drug therapy
-
Hepatitis C, Chronic / surgery*
-
Humans
-
Immunosuppressive Agents / adverse effects
-
Immunosuppressive Agents / therapeutic use
-
Interferon alpha-2
-
Interferon-alpha / therapeutic use
-
Liver Cirrhosis / etiology
-
Liver Cirrhosis / prevention & control
-
Liver Transplantation* / adverse effects
-
Liver Transplantation* / statistics & numerical data
-
Polyethylene Glycols / therapeutic use
-
Randomized Controlled Trials as Topic
-
Recombinant Proteins
-
Recurrence
-
Reoperation
-
Ribavirin / therapeutic use
-
Treatment Outcome
Substances
-
Antiviral Agents
-
Immunosuppressive Agents
-
Interferon alpha-2
-
Interferon-alpha
-
Recombinant Proteins
-
Polyethylene Glycols
-
Ribavirin
-
peginterferon alfa-2a