Three-dimensional 1H spectroscopic imaging of cerebral metabolites in the rat using surface coils

Magn Reson Imaging. 1992;10(6):965-74. doi: 10.1016/0730-725x(92)90451-5.

Abstract

Three dimensional metabolite maps of protonated metabolites were obtained using 1H magnetic resonance spectroscopic imaging at 7 T. Surface coils were used to increase sensitivity and spatial resolution significantly over a volume coil two-dimensional acquisition. Adiabatic pulses were employed to provide homogeneous B1 excitation and frequency selective refocusing over the volume of the rat brain. These techniques were employed to obtain three-dimensional spectroscopic imaging spectra from nominal voxel volumes of 9-30 microliters from rat brain. The improved spatial resolution and sensitivity are also demonstrated with studies of focal ischemia in the rat.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain Ischemia / metabolism*
  • Image Processing, Computer-Assisted*
  • Lactates / metabolism*
  • Lipid Metabolism*
  • Magnetic Resonance Spectroscopy
  • Naphthaleneacetic Acids / metabolism*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Lactates
  • Naphthaleneacetic Acids