Differentially functionalized diamines as novel ligands for the NPY2 receptor

Charles J Andres; Ildiko Antal Zimanyi; Milind S Deshpande; Lawrence G Iben; Katharine Grant-Young; Gail K Mattson; Weixu Zhai

doi:10.1016/s0960-894x(03)00554-7

Differentially functionalized diamines as novel ligands for the NPY2 receptor

Bioorg Med Chem Lett. 2003 Sep 1;13(17):2883-5. doi: 10.1016/s0960-894x(03)00554-7.

Authors

Charles J Andres¹, Ildiko Antal Zimanyi, Milind S Deshpande, Lawrence G Iben, Katharine Grant-Young, Gail K Mattson, Weixu Zhai

Affiliation

¹ Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492, USA.

PMID: 14611849
DOI: 10.1016/s0960-894x(03)00554-7

Abstract

The synthesis of novel ligands for the NPY(2) receptor using solid phase split pool methodology is described. One of the analogues, diamine 16, was found to be a potent NPY(2) binder.

MeSH terms

Acylation
Cell Line, Tumor
Diamines / chemical synthesis
Diamines / metabolism*
Humans
Inhibitory Concentration 50
Ligands
Neuroblastoma / metabolism
Radioligand Assay
Receptors, Neuropeptide Y / metabolism*
Structure-Activity Relationship

Substances

Diamines
Ligands
Receptors, Neuropeptide Y
neuropeptide Y2 receptor