Abstract
Four guaia-12,6-olide type sesquiterpene lactones, aguerin B (1), 8alpha-acetoxyzaluzanin C (2), cynaropicrin (3), and deacylcynaropicrin (4), were isolated from the flowers of Hemisteptia lyrata Bunge. It is the first report on the isolation of compounds 1-4 from Hemisteptia species. All the isolates (1-4) were examined for their cytotoxic activity against SK-OV-3, LOX-IMVI, A549, MCF-7, PC-3, and HCT-15 human cancer cell lines.
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / toxicity*
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Asteraceae*
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Cell Line, Tumor
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Drug Screening Assays, Antitumor / methods
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Flowers / toxicity*
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Humans
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Lactones / chemistry
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Lactones / isolation & purification
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Lactones / toxicity*
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / toxicity
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / toxicity*
Substances
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Antineoplastic Agents
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Lactones
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Plant Extracts
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Sesquiterpenes