MHC gene products and anticardiolipin antibodies in systemic lupus erythematosus results of a multicenter study. SLE Study Group

K Hartung; R Coldewey; A Corvetta; H Deicher; J R Kalden; F Krapf; B Lang; H J Lakomek; B Liedvogel; H H Peter

doi:10.3109/08916939209001909

MHC gene products and anticardiolipin antibodies in systemic lupus erythematosus results of a multicenter study. SLE Study Group

Autoimmunity. 1992;13(2):95-9. doi: 10.3109/08916939209001909.

Authors

K Hartung¹, R Coldewey, A Corvetta, H Deicher, J R Kalden, F Krapf, B Lang, H J Lakomek, B Liedvogel, H H Peter, et al.

Affiliation

¹ Department of Medicine, University of Hannover, FRG.

PMID: 1467439
DOI: 10.3109/08916939209001909

Abstract

Anticardiolipin antibodies (aCL) and HLA-DR antigens were determined in 314 central European patients with systemic lupus erythematosus (SLE). Both HLA-DR4 and DR7 were increased in aCL-positive patients, and aCL were significantly associated with DRw53. The association between DRw53 and aCL was also apparent in those 17 patients with SLE and the anticardiolipin syndrome. There was no association between aCL and HLA-DQ or C4 alleles in SLE.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Anticardiolipin / blood*
Antiphospholipid Syndrome / complications
Antiphospholipid Syndrome / genetics
Antiphospholipid Syndrome / immunology*
Autoimmune Diseases / genetics
Autoimmune Diseases / immunology*
Disease Susceptibility / immunology
Europe
Genetic Predisposition to Disease
HLA Antigens / analysis*
HLA Antigens / genetics
Humans
Immunoglobulin G / immunology
Immunoglobulin M / immunology
Lupus Erythematosus, Systemic / complications
Lupus Erythematosus, Systemic / genetics
Lupus Erythematosus, Systemic / immunology*
Major Histocompatibility Complex*
White People / genetics

Substances

Antibodies, Anticardiolipin
HLA Antigens
Immunoglobulin G
Immunoglobulin M