Abstract
The anticancer drug (R,S)-biscaltamide was prepared in three steps in >90% overall yield. A key step in the new synthesis involved a new nucleophilic aromatic substitution reaction of methacrylamide anion.
MeSH terms
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Acrylamides / chemistry*
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Anilides / chemical synthesis*
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Anilides / chemistry
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Anions / chemistry
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Nitriles
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Stereoisomerism
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Tosyl Compounds
Substances
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Acrylamides
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Anilides
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Anions
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Antineoplastic Agents
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Nitriles
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Tosyl Compounds
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bicalutamide
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methacrylamide