Pathological features predictive of local recurrence after management by conservation of invasive breast cancer: importance of non-invasive carcinoma

Radiother Oncol. 1992 Nov;25(3):176-80. doi: 10.1016/0167-8140(92)90264-u.

Abstract

The pathological features of 236 clinical stage I and II invasive breast carcinomas treated by conservation were reviewed. On follow-up (minimum 2 years) 13 patients (6%) have developed breast relapse, 10 (4%) regional lymph node relapse and 26 (11%) distant metastases. Nineteen patients have died from breast carcinoma. On univariate analyses lymph node metastases, increasing amounts of non-invasive carcinoma and multiple foci of invasion were significant risk factors for breast relapse. A Cox's multivariate analysis showed the first two of these to be independently significant. The results are in agreement with other published series and confirm that assessment of non-invasive carcinoma is important. The study compares simple quantitation with the original method reported to define cases with an "extensive intraduct component".

MeSH terms

  • Breast Neoplasms / pathology
  • Breast Neoplasms / therapy*
  • Combined Modality Therapy
  • Female
  • Humans
  • Lymphatic Metastasis
  • Mastectomy, Segmental
  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local*