Adaptation of a strain of Plasmodium falciparum from Ghana to Aotus lemurinus griseimembra, A. nancymai, and A. vociferans monkeys

Joann S Sullivan; James J Sullivan; Allison Williams; Katharine K Grady; Amy Bounngaseng; Curtis S Huber; Douglas Nace; Tyrone Williams; G Gale Galland; John W Barnwell; William E Collins

Adaptation of a strain of Plasmodium falciparum from Ghana to Aotus lemurinus griseimembra, A. nancymai, and A. vociferans monkeys

Am J Trop Med Hyg. 2003 Dec;69(6):593-600.

Authors

Joann S Sullivan¹, James J Sullivan, Allison Williams, Katharine K Grady, Amy Bounngaseng, Curtis S Huber, Douglas Nace, Tyrone Williams, G Gale Galland, John W Barnwell, William E Collins

Affiliation

¹ Division of Parasitic Diseases and Animal Resources Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.

PMID: 14740874

Abstract

A strain of Plasmodium falciparum from Ghana was adapted to Aotus lemurinus griseimembra, A. nancymai, and A. vociferans monkeys. Gametocytes in splenectomized A. nancymai were infective to Anopheles freeborni mosquitoes. Sporozoite transmission was accomplished in two splenectomized A. nancymai with prepatent periods of 22 and 25 days. The Ghana III/CDC strain of P. falciparum is susceptible to treatment with chloroquine and mefloquine.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adaptation, Biological*
Animals
Anopheles / parasitology
Aotidae / parasitology*
DNA Primers
Disease Models, Animal
Genotype
Ghana
Malaria Vaccines
Malaria, Falciparum / prevention & control
Plasmodium falciparum / genetics
Plasmodium falciparum / physiology*
Polymerase Chain Reaction

Substances

DNA Primers
Malaria Vaccines

Grants and funding

936-6001/PHS HHS/United States