Nucleic acid binding properties of thyminyl and adeninyl pyrrolidine-amide oligonucleotide mimics (POM)

T H Samuel Tan; David T Hickman; Jordi Morral; Ian G Beadham; Jason Micklefield

doi:10.1039/b315768g

Nucleic acid binding properties of thyminyl and adeninyl pyrrolidine-amide oligonucleotide mimics (POM)

Chem Commun (Camb). 2004 Mar 7:(5):516-7. doi: 10.1039/b315768g. Epub 2004 Jan 28.

Authors

T H Samuel Tan¹, David T Hickman, Jordi Morral, Ian G Beadham, Jason Micklefield

Affiliation

¹ Department of Chemistry, University of Manchester Institute of Science and Technology, PO Box 88, Manchester, UK M60 1QD.

PMID: 14973585
DOI: 10.1039/b315768g

Abstract

Adeninyl POM was prepared using solid-phase peptide chemistry and shown to exhibit higher affinity for complementary DNA and RNA than the corresponding adeninyl PNA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA / metabolism
Molecular Mimicry
Nucleic Acid Denaturation
Nucleic Acids / metabolism*
Oligonucleotides / chemical synthesis*
Oligonucleotides / metabolism*
Pyrrolidines / chemical synthesis*
RNA / metabolism
Spectrophotometry, Ultraviolet

Substances

Nucleic Acids
Oligonucleotides
Pyrrolidines
RNA
DNA