Cytotoxic isoquinoline quinones from sponges of the genus Petrosia

Nat Prod Res. 2004 Feb;18(1):89-93. doi: 10.1080/1057563031000122130.

Abstract

Bioassay-guided fractionation of two Philippine sponges of the genus Petrosia has resulted in the isolation of the novel natural product cribrostatin 7 (1) and the known compounds renierone (2) and O-demethylrenierone (3). The structures of these isoquinoline quinones were determined by interpretation of spectroscopic data. Compounds 1, 2 and 3 were cytotoxic against the HCT 116 human colon carcinoma cell line with IC50 values of 45, 24 and 34 microg/mL, respectively.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biological Assay
  • Carcinoma / pathology
  • Colonic Neoplasms / pathology
  • Isoquinolines / chemistry
  • Isoquinolines / isolation & purification
  • Isoquinolines / toxicity
  • Porifera / chemistry*
  • Quinones / chemistry*
  • Quinones / isolation & purification*
  • Spectrum Analysis
  • Tumor Cells, Cultured

Substances

  • Isoquinolines
  • O-demethylrenierone
  • Quinones
  • cribrostatin 7
  • renierone