Abstract
A homoisoflavanone, 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one ( 1), was isolated from the bulb of Cremastra appendiculata (D. Don) Makino (Orchidaceae) as a potent inhibitor of angiogenesis. It inhibited basic fibroblast growth factor (bFGF)-induced in vitro angiogenesis and in vivo angiogenesis of the chorioallantoic membrane (CAM) of chick embryo without showing any toxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiogenesis Inhibitors / administration & dosage
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Angiogenesis Inhibitors / pharmacology*
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Angiogenesis Inhibitors / therapeutic use
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Animals
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Chick Embryo
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Chorion / blood supply
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Chorion / drug effects
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Fibroblast Growth Factor 2 / drug effects*
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Isoflavones / administration & dosage
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Isoflavones / pharmacology
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Isoflavones / therapeutic use
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Neovascularization, Physiologic / drug effects
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Orchidaceae*
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
Substances
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Angiogenesis Inhibitors
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Isoflavones
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Plant Extracts
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Fibroblast Growth Factor 2