Abstract
[structure: see text] Two novel hybrid polyketide-terpenoid metabolites were isolated from a Penicillium sp. growing in the Berkeley Pit Lake of Butte, Montana. Their structures were deduced by spectroscopic analysis and confirmed by single-crystal X-ray analysis on berkeleydione (1). Both compounds inhibited matrix metalloproteinase-3 and caspase-1, and berkeleydione showed activity toward non-small-cell lung cancer in NCI's human cell line antitumor screen.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acids
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Caspase Inhibitors
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Cell Line, Tumor
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Crystallography, X-Ray
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Drug Evaluation, Preclinical
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Enzyme Inhibitors / analysis
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Enzyme Inhibitors / isolation & purification*
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Fresh Water / microbiology
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Humans
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Macrolides / analysis
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Macrolides / isolation & purification*
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Macrolides / pharmacology
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Magnetic Resonance Spectroscopy
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Matrix Metalloproteinase Inhibitors
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Mining
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Molecular Structure
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Montana
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Penicillium chrysogenum / chemistry*
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Penicillium chrysogenum / isolation & purification
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Penicillium chrysogenum / metabolism
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Terpenes / analysis
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Terpenes / isolation & purification*
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Terpenes / pharmacology
Substances
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Acids
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Caspase Inhibitors
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Enzyme Inhibitors
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Macrolides
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Matrix Metalloproteinase Inhibitors
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Terpenes
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berkeleydione
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berkeleytrione