Enantioselective guest binding and dynamic resolution of cationic ruthenium complexes by a chiral metal-ligand assembly

Dorothea Fiedler; Dennis H Leung; Robert G Bergman; Kenneth N Raymond

doi:10.1021/ja039225a

Enantioselective guest binding and dynamic resolution of cationic ruthenium complexes by a chiral metal-ligand assembly

J Am Chem Soc. 2004 Mar 31;126(12):3674-5. doi: 10.1021/ja039225a.

Authors

Dorothea Fiedler¹, Dennis H Leung, Robert G Bergman, Kenneth N Raymond

Affiliation

¹ Chemical Sciences Division, Lawrence Berkeley National Laboratory, and Department of Chemistry, University of California, Berkeley, California 94720, USA.

PMID: 15038695
DOI: 10.1021/ja039225a

Abstract

A supramolecular metal-ligand assembly encapsulates a variety of cationic half-sandwich ruthenium complexes. Due to the chirality of both host and guest, chiral recognition is observed with diastereomeric excesses up to 70%. The chiral cavity can be used to carry out a dynamic resolution of the rapidly equilibrating enantiomers of the chiral organometallic guest.