Abstract
Rectal instillation of trinitrobenzene sulfonic acid (TNBS) induces acute colitis in the mouse. We tested the efficacy of Yersinia pseudotuberculosis anti-inflammatory components in preventing TNBS-triggered colitis. Animals were orally inoculated with virulence-attenuated Yersinia cells (a phoP mutant) prior to TNBS administration. Under these experimental conditions, colonic lesions and tumor necrosis factor alpha mRNA levels were significantly reduced.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Colitis / chemically induced
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Colitis / immunology*
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Colitis / physiopathology
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Disease Models, Animal
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Female
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Humans
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Inflammation
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Inflammatory Bowel Diseases / immunology
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Mice
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Mice, Inbred C57BL
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Trinitrobenzenesulfonic Acid / pharmacology*
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Tumor Necrosis Factor-alpha / immunology*
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Tumor Necrosis Factor-alpha / metabolism
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Yersinia pseudotuberculosis / immunology*
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Yersinia pseudotuberculosis / pathogenicity
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Yersinia pseudotuberculosis Infections / immunology*
Substances
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Tumor Necrosis Factor-alpha
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Trinitrobenzenesulfonic Acid