Fear that terrorists can use biological agents as weapons of mass destruction is significantly impacting the conduct of microbiological research. Abundant new funds are available for biodefence research, and many researchers are racing to enter the field. There are some concerns, however, that a large emphasis on this issue could skew the microbiology research agenda. Furthermore, new responsibilities for safely conducting research with biothreat agents and concern that information might be misused could drive some researchers away from the field.