Asymmetry of salivary gland I123 metaiodobenzylguanidine (MIBG) uptake in a patient with cervical neuroblastoma and Horner's syndrome--possible etiologic mechanisms

Pediatr Radiol. 1992;22(3):225-6. doi: 10.1007/BF02012504.

Abstract

Horner's syndrome may be due to a variety of serious underlying disorders including cervical neuroblastoma. Horner's syndrome results from a unilateral disruption of the sympathetic innervation to the head and neck. We report a patient with cervical neuroblastoma in whom post operative metaiodobenzylguanidine (MIBG) scans showed a striking decrease in uptake in the ipsilateral salivary glands. Since the bio-distribution of I123 metaiodobenzylguanidine in the salivary glands in also dependent on sympathetic innervation, the presence of Horner's syndrome can be reflected in the MIBG scan.

Publication types

  • Case Reports

MeSH terms

  • 3-Iodobenzylguanidine
  • Female
  • Head and Neck Neoplasms / complications
  • Head and Neck Neoplasms / diagnosis*
  • Head and Neck Neoplasms / metabolism
  • Horner Syndrome / diagnosis*
  • Horner Syndrome / etiology
  • Horner Syndrome / metabolism
  • Humans
  • Infant, Newborn
  • Iodine Radioisotopes
  • Iodobenzenes* / pharmacokinetics
  • Male
  • Neuroblastoma / complications
  • Neuroblastoma / diagnosis*
  • Neuroblastoma / metabolism
  • Salivary Glands / innervation
  • Salivary Glands / metabolism

Substances

  • Iodine Radioisotopes
  • Iodobenzenes
  • 3-Iodobenzylguanidine