[Mannitol solution (M-400) vs. mannitol solution combined with allopurinol in the prevention of post-transfusion acute renal failure]

Actas Urol Esp. 1992 Jun;16(6):446-50.
[Article in Spanish]

Abstract

Evaluation on the incidence of Acute Renal Failure (ARF) from a total of 41 corpse renal graft receptors, 20 of which received perfusion with mannitol solution at 400 mOsm/kg (Group 1) and 21 the same mannitol solution plus allopurinol (Group 2). No significant differences were present between both groups when they were analyzed for ARF incidence (15% vs 23.8%); overall incidence was 19.5%. 24-hour initial diuresis was shown to be an excellent predictor for long-term graft functionality. We can conclude that the addition of mannitol to the perfusion solution contributes decisively to reduce post-transplantation ARF, while addition of allopurinol does not have further beneficial effects.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • English Abstract
  • Review

MeSH terms

  • Acute Kidney Injury / prevention & control*
  • Allopurinol / administration & dosage*
  • Cadaver
  • Drug Evaluation
  • Drug Therapy, Combination
  • Graft Rejection / drug effects
  • Humans
  • Kidney Transplantation*
  • Mannitol / administration & dosage*

Substances

  • Mannitol
  • Allopurinol