Probing the interaction of the biotin-avidin complex with the relaxivity of biotinylated Gd-DTPA

Sander Langereis; Homme-Auke T Kooistra; Marcel H P van Genderen; E W Meijer

doi:10.1039/b402917h

Probing the interaction of the biotin-avidin complex with the relaxivity of biotinylated Gd-DTPA

Org Biomol Chem. 2004 May 7;2(9):1271-3. doi: 10.1039/b402917h. Epub 2004 Apr 6.

Authors

Sander Langereis¹, Homme-Auke T Kooistra, Marcel H P van Genderen, E W Meijer

Affiliation

¹ Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands.

PMID: 15105914
DOI: 10.1039/b402917h

Abstract

A biotinylated Gd-DTPA complex is designed to study the biotin-avidin complexation using the longitudinal relaxivity of this new MRI label, which illustrates the use of MRI contrast agents to probe the formation of supramolecular assemblies in water.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Avidin / chemistry*
Biotin / chemistry*
Contrast Media / chemistry*
Gadolinium DTPA / chemical synthesis
Gadolinium DTPA / chemistry*
Magnetic Resonance Imaging
Molecular Structure
Protein Structure, Secondary
Water / chemistry

Substances

Contrast Media
Water
Avidin
Biotin
Gadolinium DTPA