The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis

Best Pract Res Clin Rheumatol. 2004 Feb;18(1):59-80. doi: 10.1016/j.berh.2003.09.010.

Abstract

The development of anti-TNF therapy is a key step forward in rheumatology as it is the first new therapy for based on investigating the molecular mechanisms of this disease. This chapter reviews how this discovery was made.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antirheumatic Agents / therapeutic use
  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / immunology*
  • Autoantibodies / analysis
  • Autoantibodies / drug effects
  • Clinical Trials as Topic
  • Cytokines / drug effects*
  • Cytokines / metabolism
  • Disease Models, Animal
  • Humans
  • Mice
  • RNA, Messenger / analysis
  • Research Design
  • Sensitivity and Specificity
  • Synovial Membrane / drug effects
  • Synovial Membrane / metabolism
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*
  • Tumor Necrosis Factor-alpha / therapeutic use

Substances

  • Antirheumatic Agents
  • Autoantibodies
  • Cytokines
  • RNA, Messenger
  • Tumor Necrosis Factor-alpha