Abstract
This review depicts in vitro and in vivo results obtained with nucleotide prodrugs (pronucleotides) bearing S-acyl-2-thioethyl (SATE) groups as esterase-labile phosphate protections. New developments are illustrated by the design of mononucleoside mixed phosphoester derivatives leading to the selective intracellular delivery of the corresponding 5'-mononucleotide through two different enzyme-mediated activation steps.
MeSH terms
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Animals
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Antiviral Agents / chemical synthesis
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Cell Division / drug effects
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HIV-1 / drug effects
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Hepatitis B virus / drug effects
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Humans
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Kinetics
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Nucleotides / chemical synthesis
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Nucleotides / chemistry
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Nucleotides / pharmacology*
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Organophosphates / chemistry
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Organophosphates / metabolism
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Organophosphates / pharmacokinetics
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Prodrugs / chemical synthesis
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Prodrugs / chemistry
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Prodrugs / pharmacology*
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Structure-Activity Relationship
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Time Factors
Substances
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Antiviral Agents
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Nucleotides
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Organophosphates
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Prodrugs