Long-term seizure outcome following resective surgery at National Epilepsy Center in Shizuoka, Japan

Psychiatry Clin Neurosci. 2004 Jun;58(3):S22-5. doi: 10.1111/j.1440-1819.2004.01244_6.x.

Abstract

We analyzed the seizure outcome of 357 patients who were followed for at least 2 years after resective surgeries; 282 underwent temporal lobe resection and 75 had extratemporal lobe resection. This study confirmed that resective surgery provides sustained, positive benefits with a high seizure-free rate of nearly 80% for most medically refractory patients. In patients with no MRI-detectable lesion who underwent extratemporal lobe resection, however, Engel's class I-II (seizure-free or rare seizures) was achieved in less than 50% of patients. High-resolution MRI should be performed at the early stage of disease in all patients with partial epilepsies. The findings would certainly urge clinicians to actively select surgical intervention.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Electroencephalography
  • Epilepsy / surgery*
  • Female
  • Humans
  • Japan
  • Magnetic Resonance Imaging
  • Magnetoencephalography
  • Male
  • Middle Aged
  • Neurosurgical Procedures*
  • Retrospective Studies
  • Seizures / surgery*
  • Temporal Lobe / surgery
  • Tomography, Emission-Computed, Single-Photon
  • Tomography, X-Ray Computed
  • Treatment Outcome