Abstract
The potency of an HIV DNA vaccine was enhanced in rhesus macaques by in vivo electroporation, as judged by increased onset, magnitude and duration of antibody and cell-mediated immune responses against both components of a combination Gag and Env vaccine. These data demonstrate the utility of the electroporation technology for use in large animals.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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AIDS Vaccines / administration & dosage*
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AIDS Vaccines / immunology
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Animals
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Antibodies, Viral / biosynthesis*
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Electroporation / methods*
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Gene Products, gag / immunology
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Macaca mulatta
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Vaccines, DNA / administration & dosage*
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Vaccines, DNA / genetics
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Vaccines, DNA / immunology
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Vaccines, DNA / pharmacology
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Viral Vaccines / administration & dosage
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Viral Vaccines / immunology
Substances
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AIDS Vaccines
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Antibodies, Viral
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Gene Products, gag
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Vaccines, DNA
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Viral Vaccines