Successful elimination of an invasive Aspergillus nidulans lung infection by voriconazole after failure of a combination of caspofungin and liposomal amphotericin B in a boy with chronic granulomatous disease

Pediatr Infect Dis J. 2004 Jun;23(6):584-6. doi: 10.1097/01.inf.0000130741.01940.ff.

Abstract

Chronic granulomatous disease is an inherited defect in host defense mechanisms mainly affecting neutrophil function. Pulmonary infection with Aspergillus nidulans in a child with chronic granulomatous disease could not be eliminated by a combination of caspofungin and liposomal amphotericin B. Voriconazole was successful in clearing the infection.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Amphotericin B / administration & dosage
  • Aspergillosis / complications
  • Aspergillosis / diagnosis
  • Aspergillosis / drug therapy*
  • Aspergillus nidulans / drug effects
  • Aspergillus nidulans / isolation & purification*
  • Caspofungin
  • Drug Therapy, Combination
  • Echinocandins
  • Follow-Up Studies
  • Granulomatous Disease, Chronic / complications
  • Granulomatous Disease, Chronic / diagnosis
  • Granulomatous Disease, Chronic / immunology*
  • Humans
  • Lipopeptides
  • Lung Diseases, Fungal / complications
  • Lung Diseases, Fungal / diagnosis
  • Lung Diseases, Fungal / drug therapy*
  • Male
  • Opportunistic Infections / complications
  • Opportunistic Infections / diagnosis
  • Opportunistic Infections / drug therapy*
  • Peptides / administration & dosage
  • Peptides, Cyclic*
  • Pyrimidines / administration & dosage*
  • Risk Assessment
  • Salvage Therapy
  • Treatment Outcome
  • Triazoles / administration & dosage*
  • Voriconazole

Substances

  • Echinocandins
  • Lipopeptides
  • Peptides
  • Peptides, Cyclic
  • Pyrimidines
  • Triazoles
  • Amphotericin B
  • Caspofungin
  • Voriconazole