Abstract
In this issue of Molecular Cell, Badis et al. demonstrate that autoregulated destabilization of the RPS28B mRNA is mediated by Edc3p interaction with an Rps28p/3'UTR mRNP complex. Subsequent recruitment of Dcp1p/Dcp2p to the complex appears to ensure rapid, deadenylation-independent decapping of the mRNA.
MeSH terms
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3' Untranslated Regions / genetics
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Endoribonucleases / metabolism
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RNA Cap-Binding Proteins
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RNA Caps / metabolism*
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RNA Stability / genetics*
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RNA, Messenger / genetics
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RNA, Messenger / metabolism*
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RNA-Binding Proteins / metabolism
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Ribonucleoproteins / metabolism
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Ribosomal Proteins / genetics
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Saccharomyces cerevisiae Proteins / metabolism
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Yeasts / genetics*
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Yeasts / metabolism
Substances
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3' Untranslated Regions
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RNA Cap-Binding Proteins
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RNA Caps
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RNA, Messenger
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RNA-Binding Proteins
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Ribonucleoproteins
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Ribosomal Proteins
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Saccharomyces cerevisiae Proteins
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messenger ribonucleoprotein
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DCP1 protein, S cerevisiae
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DCP2 protein, S cerevisiae
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Endoribonucleases