Variation in dinucleotide (GT) repeat sequence in the first exon of the STAT6 gene is associated with atopic asthma and differentially regulates the promoter activity in vitro

J Med Genet. 2004 Jul;41(7):535-9. doi: 10.1136/jmg.2003.015842.
No abstract available

Publication types

  • Letter
  • Multicenter Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Asthma / genetics*
  • Cell Line, Tumor
  • DNA, Neoplasm / genetics
  • DNA, Neoplasm / metabolism
  • Dinucleoside Phosphates / genetics
  • Dinucleotide Repeats / genetics*
  • Dinucleotide Repeats / physiology
  • Exons / genetics*
  • Genetic Variation / genetics*
  • Guanine / metabolism*
  • Guanine / physiology
  • Humans
  • Jurkat Cells
  • Nuclear Proteins / metabolism
  • Phenotype
  • Polymorphism, Genetic / genetics
  • Promoter Regions, Genetic / genetics*
  • Promoter Regions, Genetic / physiology
  • STAT6 Transcription Factor
  • Thymine / metabolism*
  • Thymine / physiology
  • Trans-Activators / genetics*
  • United Kingdom / epidemiology

Substances

  • DNA, Neoplasm
  • Dinucleoside Phosphates
  • Nuclear Proteins
  • STAT6 Transcription Factor
  • STAT6 protein, human
  • Trans-Activators
  • Guanine
  • Thymine