Hispanics represent 13% of the U.S. population but account for 19% of the new AIDS cases reported in 2000. The antiretroviral drug therapy used for the treatment of HIV/AIDS may cause lipodystrophy and insulin resistance, among other effects. Physical and leisure activities reduce these effects and improve the emotional and physical well-being of HIV-positive persons. This study describes physical and leisure activities, life satisfaction, depression, and body composition of HIV-positive Hispanics in Puerto Rico and compares body composition, CD4 counts, depression, leisure time, and life satisfaction of participants classified as physically active or inactive. Sixty-eight individuals were evaluated using questionnaires and biophysical measurements. Descriptive statistics and independent t tests were used for data analysis. Physically active participants had higher life satisfaction scores and healthier body composition as compared to those physically inactive. Health professionals must encourage the promotion of a physically active lifestyle among HIV-positive Hispanics.