In vitro susceptibilities of isolates of Sporothrix schenckii to itraconazole and terbinafine

Lidiane Meire Kohler; Paulo César Fialho Monteiro; Rosane Christine Hahn; Júnia Soares Hamdan

doi:10.1128/JCM.42.9.4319-4320.2004

In vitro susceptibilities of isolates of Sporothrix schenckii to itraconazole and terbinafine

J Clin Microbiol. 2004 Sep;42(9):4319-20. doi: 10.1128/JCM.42.9.4319-4320.2004.

Authors

Lidiane Meire Kohler¹, Paulo César Fialho Monteiro, Rosane Christine Hahn, Júnia Soares Hamdan

Affiliation

¹ Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270-901 Belo Horizonte, Minas Gerais, Brazil.

Abstract

Thirty isolates of the yeast form of Sporothrix schenckii were evaluated for in vitro susceptibility to itraconazole and terbinafine by the recommended NCCLS modified technique (M27-A2). The MICs of itraconazole obtained oscillated between 0.062 and 4.0 microg/ml, and those of terbinafine oscillated between 0.007 and 0.50 microg/ml; therefore, terbinafine showed greater in vitro activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antifungal Agents / pharmacology*
Cats
Horses
Humans
Itraconazole / pharmacology*
Microbial Sensitivity Tests
Naphthalenes / pharmacology*
Sporothrix / drug effects*
Sporothrix / isolation & purification
Sporotrichosis / diagnosis
Sporotrichosis / veterinary
Terbinafine

Substances

Antifungal Agents
Naphthalenes
Itraconazole
Terbinafine