Determination of susceptibilities of 26 Leptospira sp. serovars to 24 antimicrobial agents by a broth microdilution technique

Clinton K Murray; Duane R Hospenthal

doi:10.1128/AAC.48.10.4002-4005.2004

Determination of susceptibilities of 26 Leptospira sp. serovars to 24 antimicrobial agents by a broth microdilution technique

Antimicrob Agents Chemother. 2004 Oct;48(10):4002-5. doi: 10.1128/AAC.48.10.4002-4005.2004.

Authors

Clinton K Murray¹, Duane R Hospenthal

Affiliation

¹ Infectious Disease (MCHE-MDI), Brooke Army Medical Center, 3851 Roger Brooke Dr., Fort Sam Houston, TX 78234, USA.

Abstract

The MICs of 24 antimicrobials for 26 Leptospira spp. serovars were determined using a broth microdilution technique. The MICs at which 90% of isolates tested were inhibited (MIC(90)s) of cefepime, imipenem-cilastatin, erythromycin, clarithromycin, and telithromycin were all </=0.01 microg/ml. The MIC(90)s of amoxicillin, aztreonam, cefdinir, chloramphenicol, and penicillin G were >/=3.13 microg/ml. Many antimicrobials have excellent in vitro activity against Leptospira.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Drug Therapy, Combination / pharmacology
Leptospira / drug effects*
Leptospirosis / microbiology*
Microbial Sensitivity Tests

Substances

Anti-Bacterial Agents