Abstract
Recently, a pathological oscillatory network at 10 Hz including several motor areas was described in patients with idiopathic Parkinson's disease (PD). In 7 PD patients, we tested the clinical effect of subthalamic nucleus (STN) stimulation at varying frequencies 1 to 3 years after implantation of electrodes. STN stimulation at 10 Hz induced significant worsening of motor symptoms, especially akinesia, compared with no stimulation and therapeutic stimulation (> or =130 Hz). This finding indicates the clinical relevance of pathological 10 Hz synchronization in PD.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Antiparkinson Agents / adverse effects
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Antiparkinson Agents / therapeutic use
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Dominance, Cerebral / physiology
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Drug Therapy, Combination
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Electric Conductivity
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Electric Stimulation Therapy*
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Electrodes, Implanted
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Female
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Humans
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Levodopa / adverse effects
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Levodopa / therapeutic use
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Male
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Middle Aged
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Motor Activity / physiology
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Nerve Net / physiopathology
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Neurologic Examination
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Parkinson Disease / physiopathology
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Parkinson Disease / therapy*
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Stereotaxic Techniques
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Subthalamic Nucleus / physiopathology*
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Surgery, Computer-Assisted
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Treatment Failure
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Tremor / physiopathology
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Tremor / therapy
Substances
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Antiparkinson Agents
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Levodopa