Evolution of the interaction of a new chemical entity, eflucimibe, with gamma-cyclodextrin during kneading process

Eur J Pharm Sci. 2004 Oct;23(2):123-9. doi: 10.1016/j.ejps.2004.06.002.

Abstract

The aim of this study was to enhance the low solubility of eflucimibe, a new chemical entity which can be used as medicine to treat dyslipidemiae, by complexation with gamma-cyclodextrin. The complex was prepared using kneading method. The interaction evolution was studied during process by comparison of the semi-solid and physico-chemical states of the product. The evolution of the semi-solid state was followed by torque measurement when the evolution of physico-chemical state was studied by differential scanning calorimetry, infrared spectroscopy and by determination of the drug solubilisation profile. The interaction, which occurs during the process, is characterised by a modification of the product consistency and by a disappearance of the drug endothermic peaks, a disappearance of a drug spectral band and a widely improvement of the drug solubilisation profile. Indeed, after complete interaction, the drug quantity solubilised in specific conditions increased about 44-fold compared to those of untreated drug. Moreover, the comparison of the physico-chemical and semi-solid states during kneading process clearly shows that when the interaction takes place, a solidification of the paste occurs. The results of these works suggested that the formation of new solid phase allows an enhancement of the solubility of eflucimibe.

MeSH terms

  • Anilides / chemistry*
  • Calorimetry, Differential Scanning
  • Chemical Phenomena
  • Chemistry, Physical
  • Drug Compounding
  • Kinetics
  • Solubility
  • Spectrophotometry, Infrared
  • Time Factors
  • gamma-Cyclodextrins / chemistry*

Substances

  • Anilides
  • gamma-Cyclodextrins
  • eflucimibe