Abstract
This review covers the latest developments of long synthetic peptide technology for the rapid identification and development of malaria vaccine candidates and immunological modulators. A brief description of the two most common solid-phase synthetic procedures, together with the latest advances in optimisation of peptide chain assembly and analytical instrumentation, is given, with special attention to non-specialists. Several examples of vaccine candidates developed in the authors' or their collaborators' laboratories are also provided.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Antigens, Protozoan / chemistry
-
Antigens, Protozoan / immunology
-
B-Lymphocytes / immunology
-
Bee Venoms / adverse effects
-
Bee Venoms / enzymology
-
Bee Venoms / immunology
-
Chemistry, Organic / methods
-
Clinical Trials as Topic
-
Epitopes / chemistry
-
Epitopes / immunology
-
Humans
-
Hypersensitivity, Immediate / prevention & control
-
Malaria Vaccines
-
Mice
-
Mice, Inbred BALB C
-
Peptides / chemical synthesis
-
Peptides / immunology
-
Peptides / therapeutic use*
-
Phospholipases A / chemical synthesis
-
Phospholipases A / chemistry
-
Phospholipases A / immunology
-
Plasmodium falciparum / immunology
-
Plasmodium vivax / immunology
-
Protozoan Proteins / chemical synthesis
-
Protozoan Proteins / chemistry
-
Protozoan Proteins / immunology
-
T-Lymphocyte Subsets / immunology
-
Vaccines, Subunit
-
Vaccines, Synthetic
Substances
-
Antigens, Protozoan
-
Bee Venoms
-
Epitopes
-
Malaria Vaccines
-
Peptides
-
Protozoan Proteins
-
Vaccines, Subunit
-
Vaccines, Synthetic
-
Phospholipases A