Secondary metabolites by chemical screening. 9. Decarestrictines, a new family of inhibitors of cholesterol biosynthesis from Penicillium. II. Structure elucidation of the decarestrictines A to D

J Antibiot (Tokyo). 1992 Jan;45(1):66-73. doi: 10.7164/antibiotics.45.66.

Abstract

The structures of the novel 10-membered lactones, named decarestrictines A1/A2 (1/2), B (3), C1/C2 (5/6) and D (7), are presented. The structures of these secondary metabolites, isolated from different Penicillium species, were established by spectroscopic analysis and confirmed by X-ray analysis of 7 and a derivative of 3 leading to the stereochemical information. The decarestrictines vary in the oxygenation pattern between C-3 and C-7 and show structural similarities to known lactones from other fungi.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anticholesteremic Agents / chemistry*
  • Lactones / chemistry*
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Molecular Structure
  • X-Ray Diffraction

Substances

  • Anticholesteremic Agents
  • Lactones
  • decarestrictine D
  • decarestrictine B
  • decarestrictine A
  • decarestrictine C