Fundus pigment distribution in rhesus monkeys

Vet Ophthalmol. 2004 Nov-Dec;7(6):391-6. doi: 10.1111/j.1463-5224.2004.04042.x.

Abstract

There is growing evidence for an interaction among fundus pigmentation, character, geography and the function and structure of the outer retina. We examined three inbred groups of rhesus macaques (132 eyes) including all ages. One was a smaller (18 eyes) group. Coat colors were variations of brown-tan however, the smaller group had lighter 'golden' coats and colors. Fundus images were classified for pigmentation and its geographic distribution. In golden-coated animals there was bias toward nasal fundus hypopigmentation with the optic disk as a watershed demarcation zone, which extended in the superior-inferior direction. Temporal fundus hypopigmentation did not occur in the absence of nasal hypopigmentation. More common, darker coated samples showed a characteristic diffuse fundus pigmentation. There was no evidence for albinism or large variations in macular pigmentation. Rhesus monkeys can exhibit geographically controlled genetic development of fundus pigmentation. Hypopigmentation provides for access to the choroidal infrastructure.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Eye Color / physiology*
  • Female
  • Fundus Oculi*
  • Macaca mulatta / anatomy & histology*
  • Macaca mulatta / genetics
  • Male
  • Ophthalmoscopy / veterinary
  • Pigmentation / genetics
  • Pigmentation / physiology*