Intestinal obstruction due to diffuse peritoneal fibrosis at 2 years after the successful treatment of malignant peritoneal mesothelioma with intraperitoneal mitoxantrone

Cancer Chemother Pharmacol. 1992;29(5):405-8. doi: 10.1007/BF00686012.

Abstract

A 44-year-old man who had achieved a complete remission of malignant peritoneal mesothelioma after the intraperitoneal administration of 25 mg/m2 mitoxantrone presented with clinical and radiological signs of intestinal obstruction suggestive of recurrent disease at about 2 years following the initial treatment. However, laparotomy revealed extensive adhesive fibrosis but no sign of malignant mesothelioma. The peritoneal complications of intraperitoneal cytostatic treatment are discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy
  • Fibrosis / complications
  • Fibrosis / pathology
  • Humans
  • Injections, Intraperitoneal
  • Intestinal Obstruction / etiology*
  • Intestinal Obstruction / pathology
  • Jejunal Diseases / etiology*
  • Jejunal Diseases / pathology
  • Male
  • Mesothelioma / drug therapy*
  • Mesothelioma / pathology
  • Mitoxantrone / administration & dosage*
  • Peritoneal Neoplasms / drug therapy*
  • Peritoneal Neoplasms / pathology
  • Peritoneum / pathology*
  • Remission Induction
  • Time Factors
  • Tissue Adhesions / etiology
  • Tissue Adhesions / pathology

Substances

  • Mitoxantrone