Abstract
The clinical side effects of the potent new bisphosphonate zoledronic acid in children are unknown. In this study of 34 children with various bone disorders, the frequency of postinfusion flu-like illness, hypocalcemia, and hypophosphatemia was 85%, 74%, and 82%, respectively. No renal side effects were detected after up to 3 consecutive infusions.
MeSH terms
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Adolescent
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Bone Resorption / metabolism*
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Bone Resorption / prevention & control
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Calcium / blood
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Child
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Child, Preschool
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Creatinine / blood
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Diphosphonates / administration & dosage
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Diphosphonates / adverse effects*
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Female
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Fever / chemically induced
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Follow-Up Studies
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Humans
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Imidazoles / administration & dosage
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Imidazoles / adverse effects*
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Infusions, Intravenous
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Male
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Nausea / chemically induced
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Pain / chemically induced
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Phosphorus / blood
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Retrospective Studies
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Time Factors
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Urea / blood
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Vomiting / chemically induced
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Zoledronic Acid
Substances
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Diphosphonates
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Imidazoles
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Phosphorus
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Zoledronic Acid
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Urea
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Creatinine
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Calcium