Genetic confirmation of quinine-resistant Plasmodium falciparum malaria followed by postmalaria neurological syndrome in a traveler from Mozambique

J Clin Microbiol. 2004 Nov;42(11):5424-6. doi: 10.1128/JCM.42.11.5424-5426.2004.

Abstract

A case of quinine-resistant Plasmodium falciparum malaria, followed by a postmalaria neurological syndrome and a recurrence episode, is described. Genetic characterization of the P. falciparum isolate obtained by analysis of msp1 and msp2 amplicons revealed the coexistence of two genotypes causing the first malaria episode and the presence of a unique isolate responsible for the recurrence.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Antimalarials / pharmacology*
  • Drug Resistance / genetics*
  • Humans
  • L-Lactate Dehydrogenase / metabolism
  • Malaria, Cerebral / complications
  • Malaria, Cerebral / parasitology*
  • Malaria, Falciparum / complications
  • Malaria, Falciparum / parasitology*
  • Male
  • Mozambique
  • Plasmodium falciparum / classification*
  • Plasmodium falciparum / drug effects*
  • Plasmodium falciparum / genetics
  • Quinine / pharmacology*
  • Recurrence
  • Travel

Substances

  • Antimalarials
  • Quinine
  • L-Lactate Dehydrogenase