CSF characteristics in early-onset multiple sclerosis

Neurology. 2004 Nov 23;63(10):1966-7. doi: 10.1212/01.wnl.0000144352.67102.bc.

Abstract

The authors studied CSF characteristics in 136 patients with multiple sclerosis (MS) with a disease onset before age 16. In the initial diagnostic lumbar puncture, CSF-pleocytosis was observed in 66%, blood-CSF barrier dysfunction in 13%, and oligoclonal IgG in 92% of the early-onset MS (EOMS) patients. CSF oligoclonal IgG supports the early diagnosis of MS in childhood with a sensitivity similar to adult-onset MS.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Age of Onset
  • Albumins / cerebrospinal fluid
  • Cerebrospinal Fluid Proteins / analysis
  • Child
  • Child, Preschool
  • Cohort Studies
  • Diagnosis, Differential
  • Encephalomyelitis, Acute Disseminated / diagnosis
  • Female
  • Humans
  • Immunoglobulin A / biosynthesis
  • Immunoglobulin A / cerebrospinal fluid
  • Immunoglobulin G / biosynthesis
  • Immunoglobulin G / cerebrospinal fluid
  • Immunoglobulin M / biosynthesis
  • Immunoglobulin M / cerebrospinal fluid
  • Leukocytosis / etiology
  • Male
  • Multiple Sclerosis / blood
  • Multiple Sclerosis / cerebrospinal fluid*
  • Multiple Sclerosis / diagnosis
  • Multiple Sclerosis / epidemiology
  • Oligoclonal Bands / cerebrospinal fluid
  • Prospective Studies
  • Serum Albumin / analysis
  • Spinal Puncture

Substances

  • Albumins
  • Cerebrospinal Fluid Proteins
  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin M
  • Oligoclonal Bands
  • Serum Albumin