A sorting nexin PpAtg24 regulates vacuolar membrane dynamics during pexophagy via binding to phosphatidylinositol-3-phosphate

Mol Biol Cell. 2005 Feb;16(2):446-57. doi: 10.1091/mbc.e04-09-0842. Epub 2004 Nov 24.

Abstract

Diverse cellular processes such as autophagic protein degradation require phosphoinositide signaling in eukaryotic cells. In the methylotrophic yeast Pichia pastoris, peroxisomes can be selectively degraded via two types of pexophagic pathways, macropexophagy and micropexophagy. Both involve membrane fusion events at the vacuolar surface that are characterized by internalization of the boundary domain of the fusion complex, indicating that fusion occurs at the vertex. Here, we show that PpAtg24, a molecule with a phosphatidylinositol 3-phosphate-binding module (PX domain) that is indispensable for pexophagy, functions in membrane fusion at the vacuolar surface. CFP-tagged PpAtg24 localized to the vertex and boundary region of the pexophagosome-vacuole fusion complex during macropexophagy. Depletion of PpAtg24 resulted in the blockage of macropexophagy after pexophagosome formation and before the fusion stage. These and other results suggest that PpAtg24 is involved in the spatiotemporal regulation of membrane fusion at the vacuolar surface during pexophagy via binding to phosphatidylinositol 3-phosphate, rather than the previously suggested function in formation of the pexophagosome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohol Oxidoreductases / metabolism
  • Autophagy*
  • Biological Transport
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism*
  • Cell Fractionation
  • Cytosol / metabolism
  • Fluorescent Antibody Technique, Indirect
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism*
  • Genes, Fungal
  • Membrane Fusion
  • Membrane Proteins / genetics*
  • Membrane Proteins / metabolism
  • Models, Biological
  • Peroxisomes / metabolism
  • Peroxisomes / ultrastructure
  • Phosphatidylinositol Phosphates / metabolism*
  • Pichia / genetics
  • Pichia / growth & development
  • Pichia / physiology
  • Pichia / ultrastructure
  • Subcellular Fractions
  • Vacuoles / metabolism*
  • Vacuoles / ultrastructure
  • Vesicular Transport Proteins / genetics
  • Vesicular Transport Proteins / metabolism*

Substances

  • Carrier Proteins
  • Fungal Proteins
  • Membrane Proteins
  • Phosphatidylinositol Phosphates
  • Vesicular Transport Proteins
  • phosphatidylinositol 3-phosphate
  • Alcohol Oxidoreductases
  • alcohol oxidase