Abstract
Depressed patients (n = 10), schizophrenics (n = 6), and normal control subjects was (n = 9) were administered fenfluramine hydrochloride (FF) (60 mg/os) or placebo in the context of a randomized, double-blind crossover trial. No effect of FF on mood or activation was detected over a 6-hr period. A previous report claiming acute antidepressant effects of FF in depressed subjects was not confirmed.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Affect / drug effects*
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Arousal / drug effects*
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Bipolar Disorder / drug therapy*
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Bipolar Disorder / psychology
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Depressive Disorder / drug therapy*
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Depressive Disorder / psychology
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Double-Blind Method
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Female
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Fenfluramine / therapeutic use*
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Humans
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Male
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Middle Aged
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Personality Inventory
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Schizophrenia / drug therapy*
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Schizophrenic Psychology*