Abstract
Summary:
Along with their mutating sequences, protein structures change in time. Analyzing a formate dehydrogenase domain that is evolutionarily related to ferredoxin, but simultaneously contains all the structural elements of a beta-Grasp fold, we illustrate here a mechanism termed as structural drift, by which changes to a protein fold can occur.
Contact:
grishin@chop.swmed.edu.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Carrier Proteins / chemistry
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Carrier Proteins / genetics
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Evolution, Molecular*
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Ferredoxins / chemistry*
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Ferredoxins / genetics*
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Formate Dehydrogenases / chemistry*
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Formate Dehydrogenases / genetics*
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Genetic Drift*
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Membrane Proteins
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Models, Chemical*
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Models, Molecular*
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Protein Folding
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Protein Structure, Tertiary
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Protein Subunits
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Sequence Analysis, Protein / methods*
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Structure-Activity Relationship
Substances
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Carrier Proteins
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Ferredoxins
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Membrane Proteins
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Protein Subunits
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tamalin protein, human
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Formate Dehydrogenases