Expa: a program for calculating extreme pathways in biochemical reaction networks

Bioinformatics. 2005 Apr 15;21(8):1739-40. doi: 10.1093/bioinformatics/bti228. Epub 2004 Dec 21.

Abstract

The set of extreme pathways, a generating set for all possible steady-state flux maps in a biochemical reaction network, can be computed from the stoichiometric matrix, an incidence-like matrix reflecting the network topology. Here, we describe the implementation of a well-known algorithm to compute these pathways and give a summary of the features of the available software.

Availability: The C-code, along with a Windows executable and sample network reaction files, are available at http://systemsbiology.ucsd.edu

Contact: palsson@ucsd.edu.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biochemistry / methods
  • Cell Physiological Phenomena*
  • Energy Metabolism / physiology*
  • Gene Expression Regulation / physiology*
  • Humans
  • Proteome / metabolism*
  • Signal Transduction / physiology*
  • Software*

Substances

  • Proteome