Interleukin-17/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection

Infect Immun. 2005 Jan;73(1):617-21. doi: 10.1128/IAI.73.1.617-621.2005.

Abstract

We investigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protective immunity against Toxoplasma gondii. IL-17R(-/-) mice developed a normal adaptive immunity against the parasite. However, increased mortality in the knockout animals can be attributed to a defect in the migration of polymorphonuclear leukocytes to infected sites during early infection.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Movement
  • Female
  • Interleukin-17 / physiology*
  • Mice
  • Mice, Inbred C57BL
  • Neutrophils / immunology*
  • Peritoneal Cavity / cytology
  • Receptors, Interleukin / physiology*
  • Receptors, Interleukin-17
  • Signal Transduction
  • Toxoplasmosis, Animal / immunology*

Substances

  • Il17ra protein, mouse
  • Interleukin-17
  • Receptors, Interleukin
  • Receptors, Interleukin-17