Meroterpenoid MAPKAP (MK2) inhibitors isolated from the indonesian marine sponge Acanthodendrilla sp

J Nat Prod. 2004 Dec;67(12):2127-9. doi: 10.1021/np049808d.

Abstract

(+)-Makassaric acid (1) and (+)-subersic acid (2), new meroterpenoid inhibitors of the protein kinase MK2, have been isolated from the marine sponge Acanthodendrilla sp. collected in Indonesia. The structures of (+)-makassaric acid (1) and (+)-subersic acid (2) were determined by spectroscopic analysis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology
  • Indonesia
  • Inhibitory Concentration 50
  • Intracellular Signaling Peptides and Proteins
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Porifera / chemistry*
  • Protein Serine-Threonine Kinases / antagonists & inhibitors*
  • Terpenes / chemistry
  • Terpenes / isolation & purification*
  • Terpenes / pharmacology

Substances

  • Enzyme Inhibitors
  • Intracellular Signaling Peptides and Proteins
  • Terpenes
  • makassaric acid
  • subersic acid
  • MAP-kinase-activated kinase 2
  • Protein Serine-Threonine Kinases