Abstract
The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Differentiation / drug effects
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Cell Movement / drug effects
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Cells, Cultured
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Coronary Vessels / cytology
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Coronary Vessels / drug effects
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Endothelial Cells / cytology*
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Endothelial Cells / drug effects*
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Hindlimb / blood supply
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Hindlimb / drug effects
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Humans
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Ischemia / chemically induced
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Ischemia / drug therapy*
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Ischemia / metabolism
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Ischemia / pathology*
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Lymphokines
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Mice
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Microcirculation / drug effects
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Myocardium / metabolism
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Myocardium / pathology
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Neovascularization, Physiologic / drug effects*
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Phosphotyrosine / metabolism
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Platelet-Derived Growth Factor / pharmacology*
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Receptors, Platelet-Derived Growth Factor / metabolism
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Signal Transduction
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Stem Cells / cytology
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Stem Cells / drug effects*
Substances
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Lymphokines
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Platelet-Derived Growth Factor
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platelet-derived growth factor C
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Phosphotyrosine
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Receptors, Platelet-Derived Growth Factor