Magnetic resonance relaxometry in monozygotic twins discordant and concordant for schizophrenia

Eur Psychiatry. 2005 Jan;20(1):41-4. doi: 10.1016/j.eurpsy.2004.11.004.

Abstract

T1 and T2 relaxation times were examined in four pairs of monozygotic (MZ) twins discordant and concordant for schizophrenia with low and high genetic loading for the illness and five healthy control MZ twin pairs. Patients with schizophrenia (n = 11) showed significant prolongation in T1 relaxation times in the globus pallidus (GP) bilaterally (P < 0.005, Bonferroni corrected) when compared to 14 healthy MZ twins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Twin Study

MeSH terms

  • Adult
  • Antipsychotic Agents / pharmacology
  • Brain / drug effects
  • Brain / pathology*
  • Diseases in Twins / diagnosis*
  • Diseases in Twins / drug therapy
  • Diseases in Twins / genetics*
  • Female
  • Humans
  • Image Processing, Computer-Assisted / methods
  • Magnetic Resonance Imaging / methods
  • Male
  • Reference Values
  • Schizophrenia / diagnosis*
  • Schizophrenia / drug therapy
  • Schizophrenia / genetics*
  • Time Factors
  • Twins, Monozygotic*

Substances

  • Antipsychotic Agents