Transduction of the scorpion toxin maurocalcine into cells. Evidence that the toxin crosses the plasma membrane

J Biol Chem. 2005 Apr 1;280(13):12833-9. doi: 10.1074/jbc.M412521200. Epub 2005 Jan 14.

Abstract

Maurocalcine (MCa) is a 33-amino-acid residue peptide toxin isolated from the scorpion Scorpio maurus palmatus. External application of MCa to cultured myotubes is known to produce Ca2+ release from intracellular stores. MCa binds directly to the skeletal muscle isoform of the ryanodine receptor, an intracellular channel target of the endoplasmic reticulum, and induces long lasting channel openings in a mode of smaller conductance. Here we investigated the way MCa proceeds to cross biological membranes to reach its target. A biotinylated derivative of MCa was produced (MCa(b)) and complexed with a fluorescent indicator (streptavidine-cyanine 3) to follow the cell penetration of the toxin. The toxin complex efficiently penetrated into various cell types without requiring metabolic energy (low temperature) or implicating an endocytosis mechanism. MCa appeared to share the same features as the so-called cell-penetrating peptides. Our results provide evidence that MCa has the ability to act as a molecular carrier and to cross cell membranes in a rapid manner (1-2 min), making this toxin the first demonstrated example of a scorpion toxin that translocates into cells.

MeSH terms

  • Amino Acid Sequence
  • Biological Transport
  • Biotinylation
  • Calcium / chemistry
  • Carrier Proteins / chemistry
  • Cell Differentiation
  • Cell Line
  • Cell Membrane / drug effects*
  • Cell Membrane / metabolism*
  • Cell-Penetrating Peptides
  • Endocytosis
  • Endoplasmic Reticulum / metabolism
  • Gene Products, tat / metabolism
  • Humans
  • Kinetics
  • Microscopy, Confocal
  • Models, Molecular
  • Molecular Sequence Data
  • Muscle, Skeletal / cytology
  • Muscle, Skeletal / metabolism
  • Peptides / chemistry
  • Protein Conformation
  • Protein Isoforms
  • Protein Transport
  • Ryanodine / metabolism
  • Ryanodine Receptor Calcium Release Channel / chemistry
  • Sarcoplasmic Reticulum / metabolism
  • Scorpion Venoms / metabolism*
  • Scorpion Venoms / pharmacokinetics
  • Signal Transduction
  • Temperature
  • Time Factors

Substances

  • Carrier Proteins
  • Cell-Penetrating Peptides
  • Gene Products, tat
  • Peptides
  • Protein Isoforms
  • Ryanodine Receptor Calcium Release Channel
  • Scorpion Venoms
  • maurocalcine
  • Ryanodine
  • penetratin
  • Calcium