Resistance to dual nucleoside reverse-transcriptase inhibitors in children infected with HIV clade A/E

Clin Infect Dis. 2005 Jan 15;40(2):309-12. doi: 10.1086/427026. Epub 2004 Dec 21.

Abstract

The prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) mutations was determined among 95 human immunodeficiency virus-infected Thai children who were treated with dual nucleoside reverse-transcriptase inhibitors. Almost all children had resistance to at least 1 NRTI, and approximately half of the children had resistance to multiple NRTIs. Cross-resistance to stavudine and azidothymidine was universal.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Drug Resistance, Multiple, Viral* / drug effects
  • Female
  • HIV Infections / drug therapy
  • HIV Infections / virology*
  • HIV-1 / classification*
  • HIV-1 / drug effects*
  • HIV-1 / genetics
  • HIV-1 / physiology
  • Humans
  • Male
  • Mutation
  • Reverse Transcriptase Inhibitors / pharmacology*
  • Reverse Transcriptase Inhibitors / therapeutic use

Substances

  • Reverse Transcriptase Inhibitors